Dr. Willeke van Roon-Mom is head of the Huntington’s Disease Research Group at the Department of Human Genetics (LUMC, the Netherlands). Her main research focus for the past 15 years has been on Huntington’s disease (HD). In the past she studied the role of the transcription factor TATA binding protein in HD. In Leiden she has initiated new projects studying transcriptional and protein changes in a HD cell model and patient blood samples to unravel novel biomarkers of HD disease progress and pathology.
Furthermore, her lab develops therapeutic strategies for HD and other neurodegenerative disorders using specific small antibodies (VHH). Finally, she uses antisense oligonucleotides to reduce or modify the mutant huntingtin transcript and this approach is used to reduce protein toxicity in other neurodegenerative disorders. Willeke is an active member of the European Huntington’s Disease Network and a board member of the Dutch Huntington’s Disease Research Network.