The University of Milan is a public teaching and research university, which – with 8 faculties and 2 schools and a teaching staff of 2,178 professors – is distinguished by its wide variety of disciplinary fields.
A leading institute in Italy and Europe for scientific productivity, the University of Milan is the largest university in the region, with approximately 65,000 students; it is also an important resource for the socio-economic context of which it is a part.
Milan is, in fact, the capital of Lombardy, one of the most dynamic and international regions in the European Union, a leader in the national economy that stands at the Italian forefront of research and development investments and commitment to technological innovation. The University of Milan also possesses a remarkable artistic and cultural heritage that includes important historic buildings, inherited and acquired collections, archives, botanical gardens and the old Brera Observatory commissioned by Maria Teresa of Austria. The University’s departments are housed in important historic edifices in the centre of Milan and in modern buildings in the area known as Città Studi (the City of Studies).
The Research of the “Laboratory of stem cell biology and pharmacology of neurodegenerative diseases” is focused on the understanding of the factors that influence division and differentiation of neural stem cells, and on the mechanism that lead to degenerative brain diseases, such as Huntington’s Disease. The ultimate goal is to identify cells, molecules and pathways that are suitable for therapeutic intervention and novel reagents for drug screening.
Role within Neuromics
WP 10 leader. Our main tasks are the following:
-generation of hiPSC lines from selected HD patients
-testing HD phenotypes in hiPsc lines generated
-characterization of glia and neurons differentiated from hiPsc
-target identification and validation in HD animal models
- CHDI Foundation
- Impact of reduced glial-derived cholesterol in Huntington’s disease – Telethon Foundation
Workpackage 10 - Elucidation of pathogenesis and monitoring of treatment